P-Toluenesulfonyl Chloride
Zouping Jinxing Chemical Co., Ltd. is one of the leading manufacturers and suppliers of p-toluenesulfonyl chloride in China. If you're going to wholesale bulk p-toluenesulfonyl chloride made in China, welcome to get free sample from our factory. All customized products are with high quality and low price.
Physicochemical properties
Basic parameters: Melting point 65–71°C, boiling point 134°C/10 mmHg, relative density approx. 1.33 g/cm³.
Solubility: p-Toluenesulfonyl chloride is insoluble in water but readily soluble in organic solvents such as ethanol, diethyl ether, and benzene.
Reaction characteristics: Hydrolyzes slowly in contact with water to yield p-toluenesulfonic acid and hydrogen chloride; reacts vigorously upon contact with strong oxidizing agents or strong bases.
Primary Uses
TsCl is a key building block in fine organic synthesis, widely used in the following fields:
Pharmaceutical Intermediates
Used in the synthesis of antibiotics (such as cephalosporins), antivirals, and antitumor drugs to protect amino or hydroxyl groups; also serves as a core raw material for synthesizing sulfonylurea antidiabetic drugs (such as gliclazide).
Pesticide Synthesis
Acts as a key intermediate in the synthesis of high-efficiency herbicides (such as metsulfuron-methyl and bensulfuron-methyl), as well as organophosphorus insecticides and triazole fungicides.
Dye Industry
p-Toluenesulfonyl chloride is primarily used as an intermediate in the production of disperse, azo, and acid dyes, enhancing dye stability through the introduction of the sulfonyl group.
Organic Synthesis and Analysis
Used to activate carboxylic acids or act as a polymerization catalyst in the synthesis of complex molecules; employed as a derivatizing agent in analytical chemistry (gas or liquid chromatography) for the detection of alcohols and amines.
Safety, Storage, and Transportation Requirements
Health Hazards: Corrosive; causes severe skin burns and eye damage; inhalation of dust irritates the respiratory tract.
Storage Conditions: Store in a tightly sealed container in a cool, dry, and well-ventilated area; protect strictly from moisture and store separately from oxidizing agents and strong bases.
Fire-fighting Measures: Releases toxic fumes when exposed to fire; use dry chemical powder, dry sand, or carbon dioxide to extinguish fires; direct water jets are strictly prohibited.
FAQ
Q: Toxicity and Occupational Health
A: Primary hazards: Highly corrosive; releases HCl fumes upon contact with water.
Skin/Eyes: Causes severe skin burns and eye damage (H314); dust irritates mucous membranes; rabbit oral LD₅₀: 4680 mg/kg (classified as low toxicity via acute oral exposure, though corrosivity is the primary risk).
Inhalation: Dust irritates the respiratory tract, causing coughing and chest tightness.
Hydrolysis products: HCl gas + SO₂; these represent the secondary hazards requiring the most caution during handling.
Carcinogenicity/Teratogenicity: No clear evidence; not separately classified by IARC.
Core GHS statements (may vary slightly by supplier; TCI version is the most stringent):
H290: May be corrosive to metals
H314: Causes severe skin burns and eye damage
H317: May cause an allergic skin reaction (Merck/Sigma version)
H402: Harmful to aquatic life
Q: Key Points for Handling and Storage
A:Handling: Conduct inside a fume hood to control dust dispersion; exhaust gases require alkaline scrubbing (to neutralize HCl/SO₂ generated by hydrolysis).
PPE: Chemical-resistant goggles and face shield, acid-resistant gloves (butyl or Viton preferred over nitrile), chemical-resistant suit, and dust mask; handling with bare hands is strictly prohibited.
Storage: Store in a cool, dry, well-ventilated warehouse; temperature ≤25–30°C, relative humidity ≤60%; use sealed packaging (aluminum foil bags with desiccant), preferably with a nitrogen blanket.
Incompatible materials: Water, strong bases (e.g., NaOH), strong oxidizers, alcohols, and amines-reacts violently with water (hydrolysis) to release HCl.
Spills: Absorb and collect using dry sand, vermiculite, or activated carbon; do not flush with water (which accelerates the reaction); dispose of as hazardous waste containing sulfur and chlorine via a qualified facility.
Firefighting: Use dry chemical powder, CO₂, or sand; do not use water or foam (reaction with water generates heat and corrosive fumes).
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