6-Chloropurine

At room temperature, 6-chloropurine appears as a pale yellow to orange-yellow crystalline powder (high-purity grades are nearly white) and is odorless. It is soluble in hot water and sparingly soluble in ethanol and diethyl ether. It is stable when stored dry at room temperature and should be protected from light and moisture; it must not be stored with strong oxidizing agents.

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Product Introduction

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Basic physical properties

Appearance:6-Chloropurine is white to pale yellow/orange-yellow crystalline powder (whiter at higher purity; tends to yellow slightly upon exposure to light)
Melting point: >300 °C (decomposition); literature often cites 300–305 °C (dec.); no distinct atmospheric boiling point
Boiling point (estimated): Approx. 449.6 ± 25.0 °C / 760 mmHg (with decomposition)
Density: Approx. 1.65 g/cm³ (20 °C; estimated values in the 1.46–1.70 range appear in literature)
Solubility: Water ~5 g/L (20 °C); soluble in hot water, DMF, DMSO (~30 mg/mL), and dilute alkaline solutions; sparingly soluble in ethanol and diethyl ether; λmax 264 nm (0.1 M HCl, ε ≈ 8700)
pKa: Predicted 7.47 ± 0.20 (transition involving purine N-protonation/deprotonation)

Primary Uses

Pharmaceutical intermediates (core): For the production of adenine (via amination), 6-mercaptopurine (via thiolation; leukemia drug), thioguanine, nucleoside analogues (antiviral/antitumor agents), and immunosuppressant side chains
Nucleic acid building blocks: 9-alkylpurines, modified purine ligands, fluorescent probe precursors
Biochemical research: Studies on purine antimetabolite mechanisms (inhibition of HGPRT, blockade of the IMP→AMP/GMP pathway)

Safety and Physiology

Toxicity of 6-Chloropurine: Low to moderate toxicity. Oral LD₅₀ (mouse) ≈ 720 mg/kg; intraperitoneal LD₅₀ (rat) ≈ 400 mg/kg.
GHS: GHS07 (Warning); H302 (Harmful if swallowed); R22/R36/37/38 (Irritating to eyes, respiratory system, and skin); WGK 3 (Highly hazardous to water).
Handling: Use N95 dust mask, safety goggles, and nitrile gloves; weigh in a fume hood and avoid dust inhalation.
Storage and Transport: Store sealed, protected from light, and dry at 2–8°C (long-term) or at room temperature; classified as non-hazardous for transport (NONH), but store separately from strong oxidizing agents.