2-Amino-6-chloropurine (6-chloroguanine)

2-Amino-6-chloropurine (6-chloroguanine) appears as a white to pale yellow or creamy-yellow crystalline powder (whiter at higher purity; prone to slight yellowing upon exposure to light). It is soluble in hot water, dilute alkali (1 M NaOH), DMF, and DMSO, and sparingly soluble in ethanol. It is stable under dry conditions at room temperature but should be protected from light and moisture; do not store with strong oxidizing agents.

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Product Introduction

Zouping Jinxing Chemical Co., Ltd. is one of the leading manufacturers and suppliers of 2-amino-6-chloropurine (6-chloroguanine) in China. If you're going to wholesale bulk 2-amino-6-chloropurine (6-chloroguanine) made in China, welcome to get free sample from our factory. All customized products are with high quality and low price.

Basic physical properties

Appearance: White to pale yellow/cream-colored crystalline powder (whiter at higher purity; tends to turn slightly yellow upon exposure to light)
Melting point: >300 °C (decomposition); literature often cites 300–305 °C (dec.)
Boiling point: Estimated ~315 °C (accompanied by decomposition; no distinct atmospheric boiling point)
Density: Approx. 1.49–1.80 g/cm³ (literature values vary; 1.8 ± 0.1 is commonly cited)
Solubility: Water 1.7 g/L (20 °C); soluble in hot water, dilute alkali (1 M NaOH), DMF, DMSO (ultrasonic assistance aids dissolution); sparingly soluble in ethanol; λmax ≈ 218 nm (purine backbone absorption)
pKa: Predicted 6.65 ± 0.20 (purine N-protonation equilibrium)

Primary Uses

Pharmaceutical Intermediates (Core): Key precursors for synthesizing the side chains of Famciclovir, Penciclovir, and Acyclovir; also serve as building blocks for research into purine-metabolism drugs such as Nelarabine.
Nucleoside Analog Synthesis: Production of 2′-deoxyguanosine, 9-alkylpurines, and (R)/(S)-PMP purine derivatives (active against HSV, EBV, and HHV-6) via enzymatic or chemical methods.
Biochemical Reagents: Purine analogs for life science research; activity testing against EBV and HHV-6.

Safety and Physiology

Toxicity: Low toxicity, reproductive/developmental warnings. GHS: H315 Skin irritation, H319 Eye irritation, H335 Respiratory irritation, H360 May impair fertility or fetus (some suppliers label H302 Harmful if swallowed)

Handling: N95 dustproof protective gear, goggles, nitrile gloves, weigh in a fume hood, avoid inhalation of dust.

Storage and Transportation: Sealed, 2–8 ℃, dry and protected from light (long-term storage at -20 ℃); transport as a non-hazardous chemical, but store separately from strong oxidizers.

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6-Chloropurine