1-Bromo-4-nitrobenzene

1-Bromo-4-nitrobenzene (p-Bromonitrobenzene, CAS 586-78-7) is a pale yellow to off-white crystalline powder with the formula C₆H₄BrNO₂. Melting at 124–127 °C and boiling at approximately 252.6 °C, it is insoluble in water but soluble in ethanol, ether, benzene, and toluene. Mainly used as a key intermediate in pharmaceutical, dye, agrochemical, and fine-chemical synthesis, as well as a coupling substrate for liquid-crystal and OLED material intermediates. Classified as a hazardous substance (UN 3459, Class 6.1, PG III); handle under dust-controlled, dry conditions away from oxidizers, reducing agents, and strong bases.

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Product Introduction

Zouping Jinxing Chemical Co., Ltd. is one of the leading manufacturers and suppliers of 1-bromo-4-nitrobenzene in China. If you're going to wholesale bulk 1-bromo-4-nitrobenzene made in China, welcome to get free sample from our factory. All customized products are with high quality and low price.

Physicochemical properties

Appearance: 1-Bromo-4-nitrobenzene is a white to pale yellow-brown crystalline powder (often described in the literature as white prismatic crystals or an off-white to brown powder).

Melting point: 124–127 ℃
Boiling point: approx. 252–256 ℃

Density: approx. 1.72–1.95 g/cm³
Flash point: approx. 106 ℃ (closed cup)

Solubility: Insoluble in water; soluble in organic solvents such as ethanol, ether, benzene, chloroform, and ethyl acetate

Stability: Stable at room temperature; incompatible with strong oxidizing agents, strong reducing agents, and strong bases; decomposes upon heating, releasing toxic gases such as HBr and NOₓ.

Main uses

Organic synthesis building blocks: The Br site can be used for Suzuki/Stille/Buchwald cross-coupling, introducing aryl and heteroaryl groups; –NO₂ can be reduced to p-bromoaniline by palladium hydrogenation on carbon, followed by further diazotization, acylation, etc.

Pharmaceutical intermediates: Used in the synthesis of active molecules such as LSD1 inhibitors

Dye/pigment intermediates: After reduction to amino groups, they participate in the construction of azo dyes

Pesticides and fine chemicals: As a precursor containing a halogenated aromatic ring, 1-bromo-4-nitrobenzene participates in the synthesis of certain agrochemicals.

Safety and Storage

GHS Classification: Hazardous (Xn), Irritating (Xi); R20/21/22 (Hazardous if inhaled, contact with skin, or ingested), R36/37/38 (Irritating to eyes/respiratory tract/skin)

Transportation: UN 3459, Class 6.1, PG III

Handling: Weigh and transfer in a fume hood, protect from dust inhalation; wear chemical-resistant gloves, goggles, and a respirator.

Storage: Store in a cool (<30 ℃), well-ventilated, dry, and sealed place; keep away from oxidizers, reducing agents, strong alkalis, and food chemicals.

Spills: Collect and store, or contain with non-flammable absorbent material; dispose of as halogen- or nitrogen-containing hazardous waste; do not flush down the drain.

FAQ

Q: Toxicity and Occupational Health

Mechanism similar to *p*-chloronitrobenzene: metabolic reduction of the nitro group leads to methemoglobinemia (cyanosis); can be absorbed through the skin;

No reliable, standardized value for acute oral LD₅₀ (RTECS data incomplete); GHS classifications vary-ranging from Acute Tox. 3 (H301/H311/H331) to Category 4, depending on the manufacturer;

Irritation: H315 (skin irritation), H319 (serious eye irritation), H335 (respiratory irritation);

Long-term effects: H373 (damage to organs-liver/blood-through prolonged or repeated exposure);

No independent IARC carcinogenicity classification, though nitroaromatics as a class are generally managed as suspected carcinogens;

No specific PC-TWA value in China; strictly controlled by analogy to the "nitroaromatics + halogenated aromatics" category; recommended dust limit is in the 1 mg/m³ range;

GHS signal word: Warning (Danger for some brands); H302+H312+H331+H315+H319+H335+H373.

Q: Key Points for Handling and Storage

A: Three-pronged protection (dust, dermal, and heat): Conduct operations in a fume hood; use dust masks (or SCBA for high concentrations), butyl or neoprene gloves, goggles plus face shields, and chemical-resistant suits; bare-hand contact is strictly prohibited.

Storage: Keep sealed, cool (<30°C), dry, and away from light; store separately from strong oxidizers (nitrates, peroxides), strong reducing agents (e.g., Sn/HCl systems), and strong bases.

Spills: Collect using wet methods or plastic shovels; do not use dry methods that raise dust; dispose of as halogen- and nitrogen-containing hazardous waste via qualified incineration facilities (with flue gas treatment for NOx/HBr removal).

Firefighting: Use water spray, alcohol-resistant foam, dry chemical powder, or CO₂; thermal decomposition produces HBr, NOx, and CO; firefighters must wear SCBA.

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