
Methyl Propionate
Zouping Jinxing Chemical Co., Ltd. is one of the leading manufacturers and suppliers of methyl propionate in China. If you're going to wholesale bulk methyl propionate made in China, welcome to get free sample from our factory. All customized products are with high quality and low price.
Basic physical properties
CAS: 554-12-1
Boiling point: 79.7°C (almost identical to that of ethyl acetate)
Melting point: -87.5°C
Density: 0.915 g/cm³ (20°C)
Refractive index: n²⁰ᴅ ≈ 1.377
Solubility: Methyl propionate is sparingly soluble in water (approximately 6 g/100 mL at 20°C); miscible with ethanol, diethyl ether, acetone, and ethyl acetate; dissolves nitrocellulose and certain acrylic/vinyl resins
Flash point: -2°C (closed cup, CC); some literature cites 6°C (due to open-cup method differences); highly flammable liquid (GHS Category 2)
Vapor pressure: Approx. 11.35 kPa at 25°C; evaporation rate comparable to that of ethyl acetate
Explosion limits: 2.5%–13.0% v/v
Primary Uses
Fast-drying solvent: Nitrocellulose lacquers, coatings, printing inks, and adhesives (evaporation rate similar to ethyl acetate; suitable as a substitute or for blending).
Fragrances/Food flavorings: FEMA GRAS 2752; imparts apple, pineapple, and rum notes; used in soft drinks, confectionery, and baked goods (dosage in the mg/kg range).
Organic synthesis intermediate: Methyl propionate can be used to produce methyl methacrylate (MMA); intermediate for pharmaceuticals and agrochemicals; chromatographic reference standard.
Green solvent research: Derivative of bio-based propionic acid-based processes.
Safety and Physiology
Toxicity: Low toxicity. Oral LD₅₀: ~5000 mg/kg (rat), 3460 mg/kg (mouse); dermal LD₅₀: >5000 mg/kg (rabbit); inhalation LC₅₀: 27,000 mg/m³ (mouse). High vapor concentrations cause dizziness, nausea, and mucous membrane irritation; liquid contact causes moderate eye irritation.
GHS Signal Word: Danger (H225: Highly flammable liquid and vapor; H319: Causes serious eye irritation; H332: Harmful if inhaled).
Storage and Transport: UN 1248, Class 3, PG II; store in a cool, explosion-proof warehouse (≤30°C) separate from oxidizing agents and strong acids/bases; ensure anti-static grounding.
FAQ
Q: How safe is it? What should be kept in mind during operation?
A: A liquid of low toxicity and high flammability. Toxicity: LD₅₀ (rat, oral) is approximately 3.5 g/kg; it is irritating to the eyes and respiratory tract, and high concentrations of vapor may cause dizziness and nausea. Protection: Ensure good ventilation during handling; wear safety goggles and chemical-resistant gloves; strictly prohibit open flames and high temperatures.
Q: What are the requirements for storage and transportation?
A: Storage: Store in a sealed container in a cool, dark place; room temperature or refrigerated storage (2–8°C) is recommended. Containers must be tightly closed to prevent evaporation. Transport: Regulated as a flammable liquid (Category 2); flammable labels must be affixed. Not classified as highly toxic or corrosive, but avoid exposure to high temperatures or direct sunlight.
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