Methyl O-chlorobenzoate

Methyl o-chlorobenzoate appears as a colorless to pale yellow transparent liquid at room temperature. It is insoluble in water but soluble in common organic solvents such as methanol, ethanol, diethyl ether, acetone, ethyl acetate, chlorobenzene, dichloroethane, and aromatic hydrocarbons (e.g., S-100). It is stable in air and resistant to oxidation; it should be stored in a sealed container away from light.

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Product Introduction

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Basic physical properties

Appearance:Methyl O-chlorobenzoate is a colorless to pale yellow transparent liquid at room temperature (high-purity samples may crystallize at low temperatures; literature also describes it as a white to pale yellow crystalline powder, depending on purity and temperature).
Boiling point: 233–235°C (atmospheric pressure); under reduced pressure: 86–88°C/2.5 mmHg, 109–111°C/9 mmHg.
Density: 1.191 g/mL (25°C; denser than water).
Refractive index: n²⁰_D ≈ 1.536.
Flash point: 108–109°C (closed cup); classified as a combustible liquid (not a low-flash-point flammable liquid).
Vapor pressure: Approx. 0.087 mmHg (25°C); volatilizes very slowly at room temperature.
Solubility: Insoluble in water; soluble in common organic solvents such as methanol, ethanol, diethyl ether, acetone, ethyl acetate, chlorobenzene, dichloroethane, and aromatic hydrocarbons (e.g., S-100).

Primary Uses

Pharmaceutical/Agrochemical Intermediates: Synthesis of quinazolinone derivatives, o-chlorobenzohydrazide, o-chlorobenzyl alcohol, biphenyl-structured compounds, etc.
Fine Organic Synthesis: Building blocks for Suzuki coupling, ortho-lithiation, ester hydrolysis to carboxylic acids, etc.
Industrial Auxiliary Components: Metal cleaners, inks, adhesives, and coating additives (leveraging the solvency and stability of aromatic esters).
Positioned as functionalized aromatic ester intermediates rather than bulk solvents.

Safety and Toxicology

GHS: H315 (Skin irritation) / H319 (Serious eye irritation) / H335 (Respiratory irritation); Signal word: Warning; Pictogram: GHS07
Acute toxicity: Low to moderate; primary risks are irritation and accumulation upon contact; not classified as highly toxic
Protection: Handle in a fume hood; wear safety goggles, nitrile gloves, and a lab coat; avoid inhaling vapors; do not ingest or allow contact with eyes
Storage and transport:Store methyl o-chlorobenzoate below 30°C.; keep separate from strong bases and strong oxidizing agents; classified as a moderately toxic non-hazardous chemical (managed as a flammable liquid and irritant); not listed under specific UN flammable goods categories